conjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise
نویسندگان
چکیده
objective(s):this study examined whether conjugated linoleic acid (cla) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (ppar-γ) and glucose transporter type 4 (glut-4) protein expressions in the skeletal muscles of rats during endurance exercise. materials and methods:sprague-dawley male rats were randomly divided into hs (high-fat diet (hfd) sedentary group, n = 8), cs (1.0% cla supplemented hfd sedentary group, n = 8), and ce (1.0% cla supplemented hfd exercise group, n = 8). the rats in the ce swam for 60 min a day, 5 days a week for 8 weeks. results:the serum glucose and insulin contents and homeostasis model assessment of insulin resistance (homa-ir) value of the cs and ce were significantly decreased compared to those of the hs. the ppar-γ protein expressions in the soleus muscle (som) and extensor digitorum longus muscle (edl) were significantly higher in the ce than in the hs. in addition, the ppar-γ protein expression in the som of the cs was significantly higher than that in the hs. on the other hand, the glut-4 protein expression of the som in the ce was significantly higher compared to that in the hs. however, there was no significant difference in glut-4 protein expression in the edl among the groups. conclusion:cla supplementation with/without endurance exercise has role in improvement of insulin sensitivity. moreover, when cla supplementation was accompanied by endurance exercise, the ppar-γ protein expression in som and edl and the glut-4 protein expression in som were enhanced compared with the control group.
منابع مشابه
Conjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise
Objective(s):This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal muscles of rats during endurance exercise. Materials and Methods:Sprague-Dawley male rats were randomly divided into HS (high-fat diet (HFD) s...
متن کاملConjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise.
OBJECTIVES This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal muscles of rats during endurance exercise. MATERIALS AND METHODS Sprague-Dawley male rats were randomly divided into HS (high-fat diet (HFD) se...
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عنوان ژورنال:
iranian journal of basic medical sciencesجلد ۱۹، شماره ۱، صفحات ۲۰-۲۷
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