conjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise

نویسندگان

kangok cho institute of sports health science, sunmoon university, asan city, chung nam, 380-701, s. korea

youngju song institute of sports health science, sunmoon university, asan city, chung nam, 380-701, s. korea

daekeun kwon institute of sports health science, sunmoon university, asan city, chung nam, 380-701, s. korea

چکیده

objective(s):this study examined whether conjugated linoleic acid (cla) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (ppar-γ) and glucose transporter type 4 (glut-4) protein expressions in the skeletal muscles of rats during endurance exercise. materials and methods:sprague-dawley male rats were randomly divided into hs (high-fat diet (hfd) sedentary group, n = 8), cs (1.0% cla supplemented hfd sedentary group, n = 8), and ce (1.0% cla supplemented hfd exercise group, n = 8). the rats in the ce swam for 60 min a day, 5 days a week for 8 weeks. results:the serum glucose and insulin contents and homeostasis model assessment of insulin resistance (homa-ir) value of the cs and ce were significantly decreased compared to those of the hs. the ppar-γ protein expressions in the soleus muscle (som) and extensor digitorum longus muscle (edl) were significantly higher in the ce than in the hs. in addition, the ppar-γ protein expression in the som of the cs was significantly higher than that in the hs. on the other hand, the glut-4 protein expression of the som in the ce was significantly higher compared to that in the hs. however, there was no significant difference in glut-4 protein expression in the edl among the groups. conclusion:cla supplementation with/without endurance exercise has role in improvement of insulin sensitivity. moreover, when cla supplementation was accompanied by endurance exercise, the ppar-γ protein expression in som and edl and the glut-4 protein expression in som were enhanced compared with the control group.

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Conjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise

Objective(s):This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal muscles of rats during endurance exercise. Materials and Methods:Sprague-Dawley male rats were randomly divided into HS (high-fat diet (HFD) s...

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Conjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise.

OBJECTIVES This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal muscles of rats during endurance exercise. MATERIALS AND METHODS Sprague-Dawley male rats were randomly divided into HS (high-fat diet (HFD) se...

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عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۹، شماره ۱، صفحات ۲۰-۲۷

کلمات کلیدی
[ ' c o n j u g a t e d l i n o l e i c a c i d ' , ' e n d u r a n c e e x e r c i s e i n s u l i n ' , ' p p a r ' , ' γ ' , ' g l u t ' , 4 ]

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